Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis

Cancer Res. 2005 Jul 15;65(14):6167-77. Christensen C, Ambartsumian N, Gilestro GF, Thomsen B, Comoglio P, Tamagnone L, Guldberg P, Lukanidin E. We have previously shown that the expression of a semaphorin, known as a repelling cue in axon guidance, Sema3E, correlates with the ability to form lung metastasis in murine adenocarcinoma cell models. Now, besides [...]

Plexin-B3 is a functional receptor for semaphorin 5A

EMBO Rep. 2004 Jul;5(7):710-4. Epub 2004 Jun 25. Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L. Institute for Cancer Research and Treatment (IRCC), University of Torino–Medical School, 10060 Candiolo (TO), Italy. Semaphorins are a large family of molecular cues implicated in neural development and in a variety [...]

The semaphorin 4D receptor controls invasive growth by coupling with Met

Nat Cell Biol. 2002 Sep;4(9):720-4. Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro GF, Barberis D, Tamagnone L, Comoglio PM. Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy. Semaphorins are cell surface and soluble signals that control axonal guidance. Recently, semaphorin receptors (plexins) have been discovered [...]

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

Nature. 2002 Mar 14;416(6877):187-90. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S. CNR-CIOS and Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy. Ligand-dependent downregulation of tyrosine kinase receptors is a critical step for modulating their activity. Upon ligand binding, hepatocyte growth factor (HGF) receptor (Met) is polyubiquitinated [...]