The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

Nature. 2002 Mar 14;416(6877):187-90. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S. CNR-CIOS and Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy. Ligand-dependent downregulation of tyrosine kinase receptors is a critical step for modulating their activity. Upon ligand binding, hepatocyte growth factor (HGF) receptor (Met) is polyubiquitinated [...]