pySolo: a complete suite for sleep analysis in Drosophila

Bioinformatics. 2009 Jun 1; 25: 1466-1467 pySolo: a complete suite for sleep analysis in Drosophila Gilestro GF., Cirelli C. Summary: pySolo is a multi-platform software for analysis of sleep and locomotor activity in Drosophila melanogaster. pySolo provides a user-friendly graphic interface and it has been developed with the specific aim of being accessible, portable, fast [...]

Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila

Science. 2009 Apr 3;324(5923):109-12 Gilestro GF, Tononi G, Cirelli C Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, though recent work suggests a link between sleep, memory, and plasticity. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in [...]

Redundant mechanisms for regulation of midline crossing in Drosophila

PLoS ONE. 2008;3(11):e3798. Epub 2008 Nov 24. Redundant mechanisms for regulation of midline crossing in Drosophila. Gilestro GF. Research Institute of Molecular Pathology, Vienna, Austria. During development, all neurons have to decide on whether to cross the longitudinal midline to project on the contralateral side of the body. In vertebrates and invertebrates regulation of crossing [...]

Regulation of commissural axon pathfinding by slit and its Robo receptors

Annu Rev Cell Dev Biol. 2006;22:651-75. Regulation of commissural axon pathfinding by slit and its Robo receptors. Dickson BJ, Gilestro GF. Research Institute of Molecular Pathology (IMP), A-1030 Vienna, Austria. Commissural axons grow along complex pathways toward, across, and beyond the midline of the central nervous system. Taking commissural axons in the vertebrate spinal cord [...]

Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis

Cancer Res. 2005 Jul 15;65(14):6167-77. Christensen C, Ambartsumian N, Gilestro GF, Thomsen B, Comoglio P, Tamagnone L, Guldberg P, Lukanidin E. We have previously shown that the expression of a semaphorin, known as a repelling cue in axon guidance, Sema3E, correlates with the ability to form lung metastasis in murine adenocarcinoma cell models. Now, besides [...]

Plexin-B3 is a functional receptor for semaphorin 5A

EMBO Rep. 2004 Jul;5(7):710-4. Epub 2004 Jun 25. Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L. Institute for Cancer Research and Treatment (IRCC), University of Torino–Medical School, 10060 Candiolo (TO), Italy. Semaphorins are a large family of molecular cues implicated in neural development and in a variety [...]

The semaphorin 4D receptor controls invasive growth by coupling with Met

Nat Cell Biol. 2002 Sep;4(9):720-4. Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro GF, Barberis D, Tamagnone L, Comoglio PM. Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy. Semaphorins are cell surface and soluble signals that control axonal guidance. Recently, semaphorin receptors (plexins) have been discovered [...]

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

Nature. 2002 Mar 14;416(6877):187-90. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S. CNR-CIOS and Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy. Ligand-dependent downregulation of tyrosine kinase receptors is a critical step for modulating their activity. Upon ligand binding, hepatocyte growth factor (HGF) receptor (Met) is polyubiquitinated [...]